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Article

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.

mBio - 29 May 2018

Vilchèze Catherine, Copeland Jacqueline, Keiser Tracy L, Weisbrod Torin, Washington Jacqueline, Jain Paras, Malek Adel, Weinrick Brian, Jacobs William R

Abstract excerpt

Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin, poses a serious problem for global tuberculosis control strategies. Lack of a safe and convenient model organism hampers progress in combating the spread of MDR strains of Mycobacterium tuberculosis We reasoned that auxotrophic MDR mutants of M. tuberculosis would provide a safe means for...

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Identifiers

PMID: 29844114
DOI: 10.1128/mBio.00938-18
PMCID: PMC5974470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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