Article
Single-cell epigenomic variability reveals functional cancer heterogeneity.
Genome biology - 24 Jan 2017
Litzenburger Ulrike M, Buenrostro Jason D, Wu Beijing, Shen Ying, Sheffield Nathan C, Kathiria Arwa, Greenleaf William J, Chang Howard Y
Abstract excerpt
BACKGROUND: Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly create cancer heterogeneity but is difficult to detect and assess functionally. RESULTS: We develop a strategy to bridge the gap between measurement and function in single-cell epigenomics. Using single-cell chromatin accessibility...
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