Article

Functional and Optogenetic Approaches to Discovering Stable Subtype-Specific Circuit Mechanisms in Depression

2018-12-17

Abstract excerpt

<h4>Background: </h4> Using canonical correlation analysis (CCA), hierarchical clustering, and machine learning methods, we recently identified four subtypes of depression defined by distinct patterns of abnormal functional connectivity in depression-related brain networks, which in turn predicted differing clinical symptom profiles and individual differences in treatment response. However, whether and how dysfunc...

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Literature Corpus work: 9e4651b3-23ea-5c5a-b64d-eed1aac6ab13
DOI: 10.1101/498964

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