Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Dec 2012

Holmes Avram J, Lee Phil H, Hollinshead Marisa O, Bakst Leah, Roffman Joshua L, Smoller Jordan W, Buckner Randy L

Abstract excerpt

Individual differences in affective and social processes may arise from variability in amygdala-medial prefrontal (mPFC) circuitry and related genetic heterogeneity. To explore this possibility in humans, we examined the structural correlates of trait negative affect in a sample of 1050 healthy young adults with no history of psychiatric illness. Analyses revealed that heightened negative affect was associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Emotions

Share to Individuality

Share to Magnetic Resonance Imaging

Share to Multifactorial Inheritance

Share to Prefrontal Cortex

Share to Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 23238724
DOI: 10.1523/JNEUROSCI.2531-12.2012
PMCID: PMC3674506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.PMID 23238724Read ↗

Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study.Semantic proximity Read ↗

Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptomsSemantic proximity Read ↗

Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.Semantic proximity Read ↗

Whole-Cortex Mapping of Common Genetic Influences on Depression and Social DeficitsSemantic proximity Read ↗

BDNF-Dependent Effects on Amygdala-Cortical Circuitry and Depression Risk in Children and Youth.Semantic proximity Read ↗

Behavioral, Anatomical and Genetic Convergence of Affect and Cognition in Superior Frontal CortexSemantic proximity Read ↗

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder.Semantic proximity Read ↗

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.Semantic proximity Read ↗

Lingual Gyrus Surface Area Is Associated with Anxiety-Depression Severity in Young Adults: A Genetic Clustering Approach.Semantic proximity Read ↗

Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.Semantic proximity Read ↗

Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression.Semantic proximity Read ↗

Multi-scale neural signatures of major depressive, anxiety, and stress-related disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.