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Article

Investigating the shared genetic architecture between depression and subcortical volumes.

Nature communications - 2 Sept 2024

Liu Mengge, Wang Lu, Zhang Yujie, Dong Haoyang, Wang Caihong, Chen Yayuan, Qian Qian, Zhang Nannan, Wang Shaoying, Zhao Guoshu, Zhang Zhihui, Lei Minghuan, Wang Sijia, Zhao Qiyu, Liu Feng

Abstract excerpt

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood. Here, we investigate the extent of polygenic...

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PMID: 39223129
DOI: 10.1038/s41467-024-52121-y
PMCID: PMC11368965

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