Article

Impact of Klotho Genotype on Lactylation in Alzheimer’s Disease and Mechanistic Insights

2025-10-29

Abstract excerpt

<title>Abstract</title> <p>Protein lactylation has emerged as a crucial regulator in the pathogenesis of Alzheimer’s disease (AD). Although the Klotho gene (KL) has been clinically linked to AD, its role in lactylation remains unclear. Here, we investigated the influence of Klotho genotype on lactylation and related inflammatory responses. Wild-type KL and the KL F352V variant were transfected into microglia and...

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Literature Corpus work: 20fa9962-f05e-55b9-9ac2-e6faa745f1d2
DOI: 10.21203/rs.3.rs-7770928/v1

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