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LACTB, a Metabolic Therapeutic Target in Clinical Cancer Application

3 Sept 2022

Abstract excerpt

Serine beta-lactamase-like protein (LACTB) is the only mammalian mitochondrial homolog evolved from penicillin-binding proteins and β-lactamases (PBP-βLs) in bacteria. LACTB, an active-site serine protease, polymerizes into stable filaments, which are localized to the intermembrane space (IMS) of mitochondrion and involved in the submitochondrial organization, modulating mitochondrial lipid metabolism. Cancer...

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PMID: 36078157
DOI: 10.3390/cells11172749

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