Article

Mapping unexplained genetic correlations across 14 psychiatric disorders

2026-01-16

Abstract excerpt

<h4>Background</h4> Transdiagnostic genetic factor models organize shared liability across psychiatric disorders, but they may leave systematic pairwise genetic overlap unexplained. <h4>Methods</h4> Using publicly available PGC cross-disorder LD score regression genetic correlations and published five-factor genomic SEM parameters, we computed model-implied disorder correlations and derived edge-level residual g...

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Literature Corpus work: e37f2654-df5e-535c-a3f9-c8ce7e5efe21
DOI: 10.64898/2026.01.14.26344089

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