Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.

Abstract excerpt

<title>Abstract</title> <p>Evidence indicates a great degree of genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder-specific genetic architecture. Here we isolate genetic effects that are shared across 11 major psychiatric disorders (p factor) to gain further insight into genetic specificity and comorbidity over and above that contributed by...

Topics

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• Comorbidity
• Genome-Wide Association Study
• Genomics
• Mental Disorders
• Multifactorial Inheritance
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors

Identifiers and source

Literature Corpus work

9bfe6557-43a0-5aa2-bd66-5e69c0ea9103

DOI

10.21203/rs.3.rs-3782302/v1