Article
Mapping the genetic landscape across 14 psychiatric disorders.
Nature - 1 Jan 2026
Grotzinger Andrew D, Werme Josefin, Peyrot Wouter J, Frei Oleksandr, de Leeuw Christiaan, Bicks Lucy K, Guo Qiuyu, Margolis Michael P, Coombes Brandon J, Batzler Anthony, Pazdernik Vanessa, Biernacka Joanna M, Andreassen Ole A, Anttila Verneri, Børglum Anders D, Breen Gerome, Cai Na, Demontis Ditte, Edenberg Howard J, Faraone Stephen V, Franke Barbara, Gandal Michael J, Gelernter Joel, Hatoum Alexander S, Hettema John M, Johnson Emma C, Jonas Katherine G, Knowles James A, Koenen Karestan C, Maihofer Adam X, Mallard Travis T, Mattheisen Manuel, Mitchell Karen S, Neale Benjamin M, Nievergelt Caroline M, Nurnberger John I, O'Connell Kevin S, Peterson Roseann E, Robinson Elise B, Sanchez-Roige Sandra S, Santangelo Susan L, Scharf Jeremiah M, Stefansson Hreinn, Stefansson Kari, Stein Murray B, Strom Nora I, Thornton Laura M, Tucker-Drob Elliot M, Verhulst Brad, Waldman Irwin D, Walters G Bragi, Wray Naomi R, Yu Dongmei, Lee Phil H, Kendler Kenneth S, Smoller Jordan W
Abstract excerpt
Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the majority of genetic signal is shared4. While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses5, the...
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