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Article

Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals.

Biological psychiatry - 1 Feb 2021

Kember Rachel L, Merikangas Alison K, Verma Shefali S, Verma Anurag, Judy Renae, Damrauer Scott M, Ritchie Marylyn D, Rader Daniel J, Bućan Maja

Abstract excerpt

BACKGROUND: Prediction of disease risk is a key component of precision medicine. Common traits such as psychiatric disorders have a complex polygenic architecture, making the identification of a single risk predictor difficult. Polygenic risk scores (PRSs) denoting the sum of an individual's genetic liability for a disorder are a promising biomarker for psychiatric disorders, but they require evaluation in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32919613
DOI: 10.1016/j.biopsych.2020.06.026
PMCID: PMC7770066

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