Article
Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotype
2023-04-12
Abstract excerpt
Senescence is a state of indefinite cell cycle arrest associated with aging, cancer, and age-related diseases. Here, using label-based mass spectrometry, ribosome profiling and nanopore direct RNA sequencing, we explore the coordinated interaction of translational and transcriptional programs of human cellular senescence. We find that translational deregulation and a corresponding maladaptive integrated stress res...
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Identifiers and source
- Literature Corpus work
- e3719827-40ba-5755-b293-5587a2d30d61
- DOI
- 10.1101/2023.04.12.536613