Article
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype.
Molecular cell - 21 Nov 2024
Payea Matthew J, Dar Showkat A, Anerillas Carlos, Martindale Jennifer L, Belair Cedric, Munk Rachel, Malla Sulochan, Fan Jinshui, Piao Yulan, Yang Xiaoling, Rehman Abid, Banskota Nirad, Abdelmohsen Kotb, Gorospe Myriam, Maragkakis Manolis
Abstract excerpt
Senescence is a state of indefinite cell-cycle arrest associated with aging, cancer, and age-related diseases. Here, we find that translational deregulation, together with a corresponding maladaptive integrated stress response (ISR), is a hallmark of senescence that desensitizes senescent cells to stress. We present evidence that senescent cells maintain high levels of eIF2α phosphorylation, typical of ISR...
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