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Article

Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations.

Aging - 19 Apr 2023

Wechter Noah, Rossi Martina, Anerillas Carlos, Tsitsipatis Dimitrios, Piao Yulan, Fan Jinshui, Martindale Jennifer L, De Supriyo, Mazan-Mamczarz Krystyna, Gorospe Myriam

Abstract excerpt

Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given that senescent cells actively secrete proinflammatory and matrix-remodeling proteins, their accumulation in tissues of older persons has been linked to many diseases of aging. Despite intense interest in identifying robust markers of senescence, the highly heterogeneous and dynamic nature of the senescent phenotype has made...

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PMID: 37086265
DOI: 10.18632/aging.204666
PMCID: PMC10188353

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