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Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence

23 Apr 2022

Abstract excerpt

The human genome is capable of producing hundreds of thousands of different proteins and non-coding RNAs from <20 000 genes, in a co-ordinated and regulated fashion. This is achieved by a collection of phenomena known as mRNA processing and metabolism, and encompasses events in the life cycle of an RNA from synthesis to degradation. These factors are critical determinants of cellular adaptability and plasticity,...

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PMID: 35460337
DOI: 10.1111/febs.16462

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