Article

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

2019-04-10

Abstract excerpt

The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of, and promising therapeutic target for, multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo . Here, we pre...

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Literature Corpus work: e0403215-15f1-5d4f-834c-04b8b72194a9
DOI: 10.1101/604306

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