Article
Cellular proteostasis decline in human senescence
2019-11-30
Abstract excerpt
Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remained unclear. Here we demonstrate that proteostasis decline is intrinsic to human senescence. Using transcriptome-wide characterization of gene expression, splicing and translation, we found a significant deterioration i...
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Identifiers and source
- Literature Corpus work
- eda1f916-58be-5cef-af3b-517b2029ec2f
- DOI
- 10.1101/860775