Article

The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNA

2026-03-01

Abstract excerpt

Cellular senescence drives aging-related tissue dysfunction through the senescence-associated secretory phenotype (SASP), an inflammatory secretome linked to retrotransposable element (RTE) derepression. Transcriptomic and proteomic approaches have extensively characterized the senescence program, but key gaps remain: transcript abundance is a poor proxy for protein output, limited proteomic depth misses low-abund...

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Literature Corpus work: 38237d41-3d60-5960-ab3c-b05af8687def
DOI: 10.64898/2026.02.27.708233

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