Article
Declining intracellular proteostasis capacity drives misfolded protein secretion in senescent human cells
2025-09-08
Abstract excerpt
<h4>ABSTRACT</h4> Healthy protein homeostasis (‘proteostasis’) relies on tightly-regulated protein quality-control (PQC) circuits that co-ordinate sequestration and clearance of potentially toxic aggregation-prone proteins, arising from various internal or external stress throughout an organism’s lifespan. At the protein level, proteotoxic stress responses typically involve extensive poly-ubiquitylation and seque...
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Identifiers and source
- Literature Corpus work
- c9ef4469-8266-5ed6-8d1c-5f28a36346c5
- DOI
- 10.1101/2025.09.07.674107