Article

Short single-stranded DNA with putative non-canonical structures comprises a novel class of plasma cell-free DNA

2021-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Cell-free DNA (cfDNA) in human blood is currently investigated as a minimally invasive, highly informative biomarker. Here, we aimed to investigate the existence of the shorter cfDNA fragments in the blood. Using an improved cfDNA purification protocol and a 3′-end-labeling method, we found DNA fragments of approximately 50 nucleotides in human plasma, present at a molar concentration comparable...

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Literature Corpus work: e37105d4-fe13-5e10-9a9d-d82456f05a27
DOI: 10.1101/2021.05.25.445702

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