Article

Fragmentation Patterns of Human Telomeric Chromatin in Plasma cfDNA

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The unique chromatin structure at telomeres protects the linear ends of chromosomes from DNA surveillance machineries. Here, we demonstrate that circulating cell-free DNA (cfDNA) from plasma can map chromatin structure at telomeres. We find that the telomeric 6-mer repeats (TTAGGG/CCCTAA) are the most abundant circulating 6-mers in cfDNA. Telomeric sequences in cfDNA contain subnucleosomal footp...

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Literature Corpus work: ba117911-6474-54a4-8bde-59d7da3449f8
DOI: 10.64898/2026.05.28.728442

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