Article

Liquid footprinting: A novel approach for DNA footprinting using short double-stranded cell-free DNA from plasma

2024-02-12

Abstract excerpt

The diagnostic potential of short double-stranded cell-free DNA (cfDNA) in blood plasma has not been recognized, yet. Here, we present a method for enrichment of double-stranded cfDNA with an average length of about 40 base pairs from cfDNA for high-throughput DNA sequencing. This class of cfDNA is enriched at gene promoters and binding sites of transcription factors or structural DNA-binding proteins, so that a g...

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Literature Corpus work: 469daec4-fbe3-55fc-b015-63eac5995d3f
DOI: 10.1101/2024.02.09.579588

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