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Short single-stranded DNAs with putative non-canonical structures comprise a new class of plasma cell-free DNA

14 Oct 2021

Abstract excerpt

BACKGROUND: Cell-free DNA (cfDNA), which is extracellular DNA present in the circulating plasma and other body fluids, is currently investigated as a minimally invasive, highly informative biomarker. While nucleosome-sized cfDNA fragments have been investigated intensively, shorter DNA fragments in the plasma have not been studied due to several technical limitations. RESULTS: We aimed to investigate the...

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PMID: 34649537
DOI: 10.1186/s12915-021-01160-8

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