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Plasma contains ultrashort single-stranded DNA in addition to nucleosomal cell-free DNA

8 Jun 2022

Abstract excerpt

Plasma cell-free DNA is being widely explored as a biomarker for clinical screening. Currently, methods are optimized for the extraction and detection of double-stranded mononucleosomal cell-free DNA of ∼160bp in length. We introduce uscfDNA-seq, a single-stranded cell-free DNA next-generation sequencing pipeline, which bypasses previous limitations to reveal a population of ultrashort single-stranded cell-free...

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PMID: 35800774
DOI: 10.1016/j.isci.2022.104554

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