Phenotypic plasticity and genetic control in colorectal cancer evolution

Abstract excerpt

Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which phenotypic variation within a tumour is a consequence of intra-tumour genetic heterogeneity remains undetermined. Here we show that colorectal cancer cells frequently have highly plastic phenotypic traits in vivo in patient tumours. We measured the degree to which trait variation reflects genetic a...

Topics

Open a Topic to create a Post that cites this publication.

• Adaptation, Physiological
• Clone Cells
• Colorectal Neoplasms
• Exome Sequencing
• Gene Expression Regulation, Neoplastic
• Mutation
• Phenotype
• Transcription, Genetic

Identifiers and source

Literature Corpus work

e3679d74-8a4e-5185-8a7c-e5e43606bb7c

DOI

10.1101/2021.07.18.451272