Phenotypic plasticity and genetic control in colorectal cancer evolution.

doi:10.1038/s41586-022-05311-x

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Article

Phenotypic plasticity and genetic control in colorectal cancer evolution.

Nature - 1 Nov 2022

Househam Jacob, Heide Timon, Cresswell George D, Spiteri Inmaculada, Kimberley Chris, Zapata Luis, Lynn Claire, James Chela, Mossner Maximilian, Fernandez-Mateos Javier, Vinceti Alessandro, Baker Ann-Marie, Gabbutt Calum, Berner Alison, Schmidt Melissa, Chen Bingjie, Lakatos Eszter, Gunasri Vinaya, Nichol Daniel, Costa Helena, Mitchinson Miriam, Ramazzotti Daniele, Werner Benjamin, Iorio Francesco, Jansen Marnix, Caravagna Giulio, Barnes Chris P, Shibata Darryl, Bridgewater John, Rodriguez-Justo Manuel, Magnani Luca, Sottoriva Andrea, Graham Trevor A

Abstract excerpt

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show that intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer (CRC). Using spatially resolved paired...

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PMID: 36289336
DOI: 10.1038/s41586-022-05311-x
PMCID: PMC9684078

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