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Article

Putative cis-regulatory drivers in colorectal cancer.

Nature - 7 Aug 2014

Ongen Halit, Andersen Claus L, Bramsen Jesper B, Oster Bodil, Rasmussen Mads H, Ferreira Pedro G, Sandoval Juan, Vidal Enrique, Whiffin Nicola, Planchon Alexandra, Padioleau Ismael, Bielser Deborah, Romano Luciana, Tomlinson Ian, Houlston Richard S, Esteller Manel, Orntoft Torben F, Dermitzakis Emmanouil T

Abstract excerpt

The cis-regulatory effects responsible for cancer development have not been as extensively studied as the perturbations of the protein coding genome in tumorigenesis. To better characterize colorectal cancer (CRC) development we conducted an RNA-sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline-genotyped. By investigating...

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Identifiers

PMID: 25079323
DOI: 10.1038/nature13602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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