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Article

Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa.

International journal of cancer - 1 Sept 2021

Vaughan-Shaw Peter G, Timofeeva Maria, Ooi Li-Yin, Svinti Victoria, Grimes Graeme, Smillie Claire, Blackmur James P, Donnelly Kevin, Theodoratou Evi, Campbell Harry, Zgaga Lina, Din Farhat V N, Farrington Susan M, Dunlop Malcolm G

Abstract excerpt

Site-specific variation in colorectal cancer (CRC) incidence, biology and prognosis are poorly understood. We sought to determine whether common genetic variants influencing CRC risk might exhibit topographical differences on CRC risk through regional differences in effects on gene expression in the large bowel mucosa. We conducted a site-specific genetic association study (10 630 cases, 31 331 controls) to...

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Identifiers

PMID: 33937989
DOI: 10.1002/ijc.33616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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