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A single <i>Citrobacter rodentium</i> infection in Pink1 knockout and wildtype mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss

2024-12-24

Abstract excerpt

A growing body of research suggests a link between immune system activation and the development of Parkinson’s disease (PD). Previous work showed that repeated gastrointestinal infection with Citrobacter rodentium can induce PD-like motor dysfunction in Pink1 knockout (KO) mice, along with immune cell infiltration into the brain. To better understand mechanisms underlying immune-mediated brain attack in this mod...

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Literature Corpus work
1642b337-1ecd-569a-b2d6-18d9ac4c2ee9
DOI
10.1101/2024.12.24.630165
Open publication

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A single <i>Citrobacter rodentium</i> infection in Pink1 knockout and wildtype mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal lossDOI 10.1101/2024.12.24.630165
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