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Modeling gene-environment interactions in Parkinson’s Disease: <i>Helicobacter pylori</i> infection of <i> Pink1 <sup>−/−</sup> </i> mice induces CD8 T cell-dependent motor and cognitive dysfunction

2024-02-26

Abstract excerpt

Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by progressive loss of motor function. Diagnosis occurs late: after motor symptom development downstream of the irreparable loss of a large proportion of the dopaminergic neurons in the substantia nigra of the brain. Understanding PD pathophysiology in its pre-motor prodromal phase is needed for earlier diagnosis and intervention. Gene...

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Literature Corpus work
9f60c082-b5ee-5f8d-8c54-fa86b2d1412d
DOI
10.1101/2024.02.25.580545
Open publication

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Modeling gene-environment interactions in Parkinson’s Disease: <i>Helicobacter pylori</i> infection of <i> Pink1 <sup>−/−</sup> </i> mice induces CD8 T cell-dependent motor and cognitive dysfunctionDOI 10.1101/2024.02.25.580545
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