Article
Abnormal RNA stability in amyotrophic lateral sclerosis.
Nature communications - 20 Jul 2018
Tank E M, Figueroa-Romero C, Hinder L M, Bedi K, Archbold H C, Li X, Weskamp K, Safren N, Paez-Colasante X, Pacut C, Thumma S, Paulsen M T, Guo K, Hur J, Ljungman M, Feldman E L, Barmada S J
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA homeostasis, but it remains unclear whether RNA stability is affected in these disorders. We use Bru-seq and BruChase-seq to assess genome-wide RNA stability in ALS patient-derived cells, demonstrating profound destabilization of ribosomal and...
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