Article

Defining and exploiting the developmental origin of MLL-AF4-driven infant Acute Lymphoblastic Leukaemia

2020-01-01

Abstract excerpt

Infant MLL-AF4-driven pro-B Acute Lymphoblastic Leukaemia (ALL) is the most common leukaemia in infants. This devastating disease, which arises in utero, renders the infant patients with an aggressive disease and with a 5-year survival rate of less than 50%. It has long been speculated that along with the fusion protein, the foetal origin of the disease is one of the main contributing factors to its aggressive nat...

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Literature Corpus work: e32c18f7-c62b-59a2-b06e-9fab554ef2d0
DOI: 10.7488/era/476

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