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The Origin of B-cells: Human Fetal B Cell Development and Implications for the Pathogenesis of Childhood Acute Lymphoblastic Leukemia

17 Feb 2021

Abstract excerpt

Human B-lymphopoiesis is a dynamic life-long process that startsin uteroby around six post-conception weeks. A detailed understanding of human fetal B-lymphopoiesis and how it changes in postnatal life is vital for building a complete picture of normal B-lymphoid development through ontogeny, and its relevance in disease. B-cell acute lymphoblastic leukemia (B-ALL) is one of the most common cancers in children,...

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Identifiers

PMID: 33679795
DOI: 10.3389/fimmu.2021.637975

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