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Single cell mRNA signals reveal a distinct developmental state of <i>KMT2A</i> -rearranged infant B-cell acute lymphoblastic leukemia

2021-12-18

Abstract excerpt

Infant B-cell acute lymphoblastic leukemia (B-ALL) has not followed the increasing trend towards cure seen in other childhood B-ALLs. The prognosis for infants with KMT2A gene fusions is especially poor, and the origins of this aggressive leukemia remain unknown. Here, we investigated the developmental state of KMT2A -rearranged infant B-ALL within hematopoietic hierarchies of human fetal bone marrow, using bulk...

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Literature Corpus work
47c38d79-a409-5e51-b52e-6a29e1453606
DOI
10.1101/2021.12.17.473141
Open publication

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Single cell mRNA signals reveal a distinct developmental state of <i>KMT2A</i> -rearranged infant B-cell acute lymphoblastic leukemiaDOI 10.1101/2021.12.17.473141
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