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Article

In Utero Development and Immunosurveillance of B Cell Acute Lymphoblastic Leukemia.

Current treatment options in oncology - 1 Apr 2022

Rüchel Nadine, Jepsen Vera H, Hein Daniel, Fischer Ute, Borkhardt Arndt, Gössling Katharina L

Abstract excerpt

OPINION STATEMENT: Acute lymphoblastic leukemia (ALL) is the most frequent type of pediatric cancer with a peak incidence at 2-5 years of age. ALL frequently begins in utero with the emergence of clinically silent, preleukemic cells. Underlying leukemia-predisposing germline and acquired somatic mutations define distinct ALL subtypes that vary dramatically in treatment outcomes. In addition to genetic...

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Identifiers

PMID: 35294722
DOI: 10.1007/s11864-022-00963-3
PMCID: PMC8924576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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