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A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

2020-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured 1 , the prognosis of infant-ALL (diagnosis within the first year of life) remains dismal 2 . Infant-ALL is usually caused by a single genetic hit that arises in utero : rearrangement of the MLL/KMT2A gene ( MLL-r ). This is sufficient to give rise to a uniquely aggressive and treatment-refractory leukemia compare...

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Literature Corpus work
9a0d3425-c948-5803-965a-16b9b1344890
DOI
10.1101/2020.11.15.379990
Open publication

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A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALLDOI 10.1101/2020.11.15.379990
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