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Article

A human genome editing–based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features

27 Sept 2023

Abstract excerpt

Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.

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Identifiers

PMID: 37756522
DOI: 10.1182/blood.2023020858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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