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Article

The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.

Genes, chromosomes & cancer - 1 Oct 2013

Dobbins Sara E, Sherborne Amy L, Ma Yussanne P, Bardini Michela, Biondi Andrea, Cazzaniga Giovanni, Lloyd Amy, Chubb Daniel, Greaves Mel F, Houlston Richard S

Abstract excerpt

Over 90% of infants (< 1-year-old) diagnosed with leukemia have pro-B acute lymphoblastic leukemia (ALL) containing the MLL-AF4 fusion. When compared with other forms of paediatric ALL affecting later B-cell differentiation, MLL-AF4 pro-B is associated with a dismal prognosis with a typical 5-year disease-free survival of <20%. MLL-AF4 may be sufficient on its own for leukemogenesis or the gene-fusion product may...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to INDEL Mutation

Share to Loss of Heterozygosity

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 23893660
DOI: 10.1002/gcc.22090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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