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Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements

1 Oct 2021

Abstract excerpt

Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding of the unique biology of this disease, particularly its prenatal origin, has hindered improvement of survival. We perform multiple RNA sequencing experiments on fetal, neonatal, and adult hematopoietic stem and progenitor cells from human and mouse. This allows definition of a conserved...

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PMID: 34706236
DOI: 10.1016/j.celrep.2021.109900

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