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Article

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

5 Dec 2018

Abstract excerpt

Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Young cells give rise to myeloid, lymphoid or mixed phenotype acute leukaemia, whereas adult cells...

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PMID: 30538250
DOI: 10.1038/s41467-018-07584-1

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