Article

IL-2 enhances effector function but suppresses follicular localization of CD8 <sup>+</sup> T cells in chronic infection

2024-05-02

Abstract excerpt

<h4>Summary</h4> Cytotoxic CD8 + T cells, essential in combating viral infections and cancer, become dysfunctional from prolonged antigen exposure. Precursors of exhausted T (T PEX ) cells are pivotal in sustaining immune responses in chronic diseases and mediating immunotherapy efficacy. They also control viral infection within B-cell follicles, facilitated by CXCR5 expression. How cytokines regulate T PEX ce...

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Literature Corpus work: e3189fab-06c1-5ea5-9025-129e9156e090
DOI: 10.1101/2024.05.02.592184

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