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Article

Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.

Nature immunology - 1 Dec 2021

Snell Laura M, Xu Wenxi, Abd-Rabbo Diala, Boukhaled Giselle, Guo Mengdi, Macleod Bethany L, Elsaesser Heidi J, Hezaveh Kebria, Alsahafi Nirmin, Lukhele Sabelo, Nejat Sara, Prabhakaran Ramanandan, Epelman Slava, McGaha Tracy L, Brooks David G

Abstract excerpt

Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T (TH) cell responses or the ability to restore CD4+ TH-mediated immunity by checkpoint blockade. We demonstrate that PD-1:PD-L1 specifically suppressed CD4+ TH1 cell amplification, prevents CD4+ TH1...

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Identifiers

PMID: 34795443
DOI: 10.1038/s41590-021-01060-7
PMCID: PMC10286806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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