Article

Differentiating PD-1+ stem-like CD8 T cells towards distinct effectors with enhanced therapeutic potential by an engineered IL-2 cis-targeted to PD-1

2021-03-17

Abstract excerpt

<title>Abstract</title> <p>Expansion of antigen-specific effector CD8 T cells is central to the control of chronic viral infections and cancer. In particular, differentiation of antigen-experienced, PD-1+TCF-1+ stem -like CD8 T cells, termed here “resource T cells”, into effector cells is critical for the success of immunotherapies based on immune checkpoint PD-1 signaling blockade1-4. In the accompanying article...

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Literature Corpus work: c155bedf-43f0-5aea-a922-5bebafc1cc31
DOI: 10.21203/rs.3.rs-329812/v1

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