Article

Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19

2021-03-26

Abstract excerpt

The contributions of T cells infiltrating the lungs to SARS-CoV-2 clearance and disease progression are poorly understood. Although studies of CD8+ T cells in bronchoalveolar lavage and blood have suggested that these cells are exhausted in severe COVID-19, CD4+ T cells have not been systematically interrogated within the lung parenchyma. We establish here that cytotoxic CD4+ T cells (CD4+CTLs) are prominently exp...

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Literature Corpus work: ee1e0b2d-1a41-5364-bda1-ea47e6133fd7
DOI: 10.1101/2021.03.23.21253885

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