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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

28 Sept 2022

Abstract excerpt

Abstract Expansion and differentiation of antigen-experienced PD-1 + TCF-1 + stem-like CD8 + T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade 1–4 . Hashimoto et al. have shown that, in chronic infections, administration of the cytokine interleukin (IL)-2 triggers an alternative differentiation path of stem-like T cells towards a distinct population of ‘better...

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PMID: 36171284
DOI: 10.1038/s41586-022-05192-0

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