Article

Expansion of Cytotoxic CD4+ T Cells in the Lungs in Severe COVID-19

2021-03-26

Abstract excerpt

The contributions of T cells infiltrating the lungs to SARS-CoV-2 clearance and disease progression are poorly understood. Although studies of CD8+ T cells in bronchoalveolar lavage and blood have suggested that these cells are exhausted in severe COVID-19, CD4+ T cells have not been systematically interrogated within the lung parenchyma. We establish here that cytotoxic CD4+ T cells (CD4+CTLs) are prominently ex...

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Literature Corpus work: 23ca6c9c-ab6f-54fb-a3fb-29eb9b28400f
DOI: 10.2139/ssrn.3813278

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