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Article

Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2015

Erickson John J, Lu Pengcheng, Wen Sherry, Hastings Andrew K, Gilchuk Pavlo, Joyce Sebastian, Shyr Yu, Williams John V

Abstract excerpt

Acute viral infections typically generate functional effector CD8(+) T cells (TCD8) that aid in pathogen clearance. However, during acute viral lower respiratory infection, lung TCD8 are functionally impaired and do not optimally control viral replication. T cells also become unresponsive to Ag during chronic infections and cancer via signaling by inhibitory receptors such as programmed cell death-1 (PD-1). PD-1...

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Identifiers

PMID: 26401005
DOI: 10.4049/jimmunol.1403004
PMCID: PMC4733528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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