Back to search

Article

Novel MprF amino acid mutations contributing to daptomycin non-susceptibility

2019-09-23

Abstract excerpt

<h4>Background: </h4> Daptomycin (DAP) is a cyclic lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, and use to treat infections due to methicillin-resistant Staphylococcus aureus (MRSA). It was reported that MprF that is bacterial membrane protein and affect to DAP non-susceptible (DAP-NS), and it was generally considered that electrically repulsion by MprF mutation was thou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e30a4e9f-412e-5b42-ac1f-061c3ab12d8f
DOI
10.21203/rs.2.14823/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Novel MprF amino acid mutations contributing to daptomycin non-susceptibilityDOI 10.21203/rs.2.14823/v1
Single nucleotide polymorphism leads to daptomycin resistance causing amino acid substitution-T345I in MprF of clinically isolated MRSA strains.Semantic proximity
Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.Semantic proximity
Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides.Semantic proximity
The Role of mprF Mutations in Seesaw Effect of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Isolates.Semantic proximity
Effect of a Point Mutation in mprF on Susceptibility to Daptomycin, Vancomycin, and Oxacillin in an MRSA Clinical StrainSemantic proximity
Down-regulation of the two-component system and cell-wall biosynthesis-related genes was associated with the reversion to daptomycin susceptibility in daptomycin non-susceptible methicillin-resistant Staphylococcus aureus.Semantic proximity
Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates.Semantic proximity
VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus.Semantic proximity
Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.Semantic proximity
Impact of Multiple Single-Nucleotide Polymorphisms Within mprF on Daptomycin Resistance in Staphylococcus aureus.Semantic proximity
Whole-genome sequencing identifies MprF mutations in a genetically diverse population of daptomycin non-susceptible Staphylococcus aureus in Australia.Semantic proximity
Characterization of genetic changes associated with daptomycin nonsusceptibility in Staphylococcus aureus.Semantic proximity
Select a neighboring publication to make it the new centre.