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Article

Single nucleotide polymorphism leads to daptomycin resistance causing amino acid substitution-T345I in MprF of clinically isolated MRSA strains.

PloS one - 1 Jan 2021

Nakamura Masaki, Kawada Hayato, Uchida Hiroki, Takagi Yusuke, Obata Shuichi, Eda Ryotaro, Hanaki Hideaki, Kitasato Hidero

Abstract excerpt

Daptomycin (DAP) is one of the most potent antibiotics used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Due to an increase in its administration for combating MRSA infections, DAP non-susceptible (DAP-NS) MRSA strains have recently been reported in clinical settings. The presence of single nucleotide polymorphisms (SNPs) in the multiple peptide resistance factor (mprF) gene...

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Identifiers

PMID: 33481910
DOI: 10.1371/journal.pone.0245732
PMCID: PMC7822245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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