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The Role of mprF Mutations in Seesaw Effect of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Isolates.

Antimicrobial agents and chemotherapy - 18 Jan 2022

Jiang Shengnan, Zhuang Hemu, Zhu Feiteng, Wei Xiang, Zhang Junxiong, Sun Lu, Ji Shujuan, Wang Haiping, Wu Dandan, Zhao Feng, Yan Rushuang, Yu Yunsong, Chen Yan

Abstract excerpt

The emergence of daptomycin-resistant (DAP-R) Staphylococcus aureus strains has become a global problem. Point mutations in mprF are the main cause of daptomycin (DAP) treatment failure. However, the impact of these specific point mutations in methicillin-resistant S. aureus (MRSA) strains associated with DAP resistance and the "seesaw effect" of distinct beta-lactams remains unclear. In this study, we used three...

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Identifiers

PMID: 34662187
DOI: 10.1128/AAC.01295-21
PMCID: PMC8765318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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